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Maria SibiliaName & Address
Maria Sibilia – Professor for Cellular and Molecular Tumorbiology
Current Position: Head of the Institute of Cancer Research
Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center (CCC), Medical University of Vienna, Borschkegasse 8a, 1090 Vienna, Austria
Phone:  +43-1-40160-57502; FAX:  +43-1-40160-957502
e-mail: maria.sibilia@meduniwien.ac.at                                              ORCID: 0000-0001-6129-5613
Web: http://krebsforschung.meduniwien.ac.at
CV (PDF)

Main Research Interests
My group employs genetically engineered mouse models (GEMMs), human tumor patient material and primary cell cultures as model systems to unravel the molecular mechanisms leading to inflammatory diseases and cancer focusing especially on squamous cell carcinomas as well as  liver and colorectal cancers. Our long-standing interest lies in understanding how EGFR signaling pathways lead to tumor development. We investigate the cell-specific role of EGFR signaling in cancer and tumor stromal cells and their complex interaction and have made major discoveries in this field. Moreover, we aim to understand how inflammatory cells in particular macrophages and plasmacytoid Dendritic Cells (pDC) influence inflammatory diseases and affect tumor development and regression. We exploit novel concepts to modulate tumors to become more sensitive to current immunomodulatory therapies with the ultimate goal is to translate this knowledge to patients to develop more effective personalized treatments for human cancer. The experimental strategies employed include molecular and biochemical approaches, various immunological assays, primary cell cultures and genetic engineering in mice.

Scientific Education and Career History
Since 2010        Head of the Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center (CCC), Medical University of Vienna, Vienna, Austria
Since 2007        Full Professor for Cellular and Molecular Tumorbiology, Head of the Research Unit Cellular and Molecular Tumorbiology Institute for Cancer Research, Department of Medicine I, Medical University of Vienna, Vienna, Austria
2002 – 2007      Associate Professor at the Department of Dermatology, DIAID, University of Vienna Medical School, Vienna, Austria
July 2002           Venia docendi (Habilitation) in Molecular Biology and Genetics
1999 – 2002      Assistant Professor at the Department of Dermatology, DIAID, University of Vienna Medical School, Vienna, Austria
1996 – 1998      Staff Scientist at the Institute of Molecular Pathology (IMP), Vienna, Austria
1993 – 1996      Postdoctoral fellow at the Institute of Molecular Pathology (IMP), Vienna, Austria
1990 – 1992      Ph.D. Studies in Genetics and Molecular Biology, University of Pavia and Department of Biotechnology and Virology, Brescia, Italy
1984 – 1989      Study of Biological Sciences, University of Pavia, Italy and Experimental thesis (Laurea), Department of Genetics and Microbiology, University of Pavia, Italy with distinction.
1970 – 1984      Schools in Thusis and Chur (GR), Switzerland

Experience in Scientific Management, Organization & Student Supervision (selected)
Since 1999      Supervisor of 16 Postdocs, 15 PhD students (10 already finished), >20 Master students; Many PhD students and PostDocs received several prizes, awards and fellowships, like fellowships from l’Oréal Women in Science, DOC-Austrian Academy of Sciences. Sanofi-Aventis prize, best PhD thesis awards, poster and best oral presentation awards.
Since 2007      Program Coordinator of the international PhD program ”Inflammation and Immunity” (IAI), funded by the FWF after competitive selection and regular evaluation (3year interval).
Since 2008      Academic Career Mentor for young women in science within the Gender Mainstreaming program of the Medical University of Vienna Member, Austria.
Since 2009      Co-Organizer: Annual International PhD Symposium of the PhD program “Inflammation and Immunity”, Austria (organized by PhD student)
Since 2010      Coordinator of oncological research within the CCC and speaker of MedUniWien Oncolgy Cluster
Since 2013      Meeting committee: Symposium on Hormones and Cell Regulation of the European Society of Endocrinology, Mont Ste Odile, Alsace, France
2015                Co-Organizer: European Cancer Congress 2015 of the European Cancer Organisation (ECCO), Vienna, Austria
2015                Organizer of the Symposium “Hormones, Metabolism and Cancer”, 40th Symposium on Hormones and Cell Regulation, European Society of Endocrinology (ESE), Mont Ste Odile, France
2018                Organizer of the 2018 EMBO Conference on Cellular signalling, Dubrovnik/Cavtat, Croatia

Supervision of Doctoral (PhD) Thesis Students (past five years – 15 since 2000)
Nicole Amberg- PhD Student 2012-2016
“The effect of inflammation on stem cells of the skin”
Karin Komposch - PhD Student 2012-2016
“Role of EGFR in liver fibrosis and cancer”
Gabriel Stulnig - PhD Student 2012-2017 (thesis in preparation)
“Mechanisms of anti-tumor response mediated by Imiquimod”
Markus Linder - PhD Student 2013-2017 (thesis in preparation)
“The role of inflammatory cells in bone tumors and bone metastasis formation”
Jörg Klufa PhD Student 2014-ongoing
“EGFR controls epidermal homeostasis and skin inflammation”
Philipp Novoszel - PhD Student 2014-ongoing


“AP1 proteins in skin tumor development and inflammation”

Invited Conference Lectures (5 recent selected)

  • 2016 - Invited talk, EMBO meeting ‘Cellular Signaling and Cancer Therapy’, Cavtat, Croatia.
  • 2017 - January: Invited talk at the EMBO Workshop “Cell death, inflammation and Cancer”, Obergurgl, Austria.
  • 2017 - Invited talk at 26th Conference of the Asian Pacific Association for the Study of the Liver (APASL Annual Meeting 2017), Shanghai, China.
  • 2017 - Invited talk at the 2nd European Association for Cancer Research EACR-OECI Conference “Making it Personal: Cancer Precision Medicine”, Amsterdam, Netherlands.
  • 2017 - Invited talk, OMICs 2.0 conference “Advances in Biomedical Research” conference, Split, Croatia.

 

Honors & Awards

  • 2005 - Alois-Sonnleitner Prize, Austrian Academy of Sciences (ÖAW) for outstanding achievements in Cancer Research
  • 2012 - Elected as EMBO Member (European Molecular Biology Organization)
  • 2012 - Prize of the City of Vienna for Medical Sciences
  • 2013 - Elected corresponding member of the Austrian Academy of Sciences
  • 2014 - Italian Order of knighthood: Commander from the Order of Merit of the Italian Republic for outstanding scientific achievements
  • 2016 - ERC-Advanced Grant - 694883 TNT-Tumors

Member of Reviewing Panels, Editorial Boards, Scientific Organizations (5 selected)

  • Reviewer for journals, including Nature Cell Biology, Nature Comm., Cell Reports, Cancer Cell, Dev. Cell, EMBO J., Cancer Res. MCB, JBC, JCB, Development, Oncogene, JID, JCI, Hepatology, Journal of Clinical Oncology (Editorial Board). etc.
  • Frequent reviewer for various funding agencies: MRC (UK), Welcome Trust, ERC, EMBO (fellowships), AICR, DFG, ISF, Dutch and Belgian Cancer Foundation
  • Member of the Board (Kuratorium) of the Austrian Sceince Funds (FWF)
  • Member of the selection committee for Austrian L’OREAL-women in science fellowships
  • Selection Committee member of the EMBO Young Investigator Program (YIP), 2013 - 2016

Most Important Research Funding (past 5 years)

  • 2017 - 2020, WWTF - Personalized medicine - 999 k€
  • 2016 - 2021, ERC - TNT-Tumors - 2.500 k€
  • 2012 - 2017, FWF (SFB) - Transmembrane transporters in health and disease - 589 k€
  • 2007 – 2019, FWF (DK) - Inflammation and Immunity (+administration) - 1.920 k€
  • 2009 - 2012, FFG GENAU III - Austrian Network for functional Mouse Genetics - 245 k€

Key International collaborations (5 selected)

  • Marco Colonna            University of St Louis, USA                                                  mcolonna@wustl.edu
  • Erwin F. Wagner         CNIO, Madrid, ESP                                                                          ewagner@cnio.es
  • Cedric Blanpain          University of Brussels, BEL                                                       labblanp@ulb.ac.be
  • Fortunato Ciardiello   University of Naples, ITA                                                      fortunato.ciardiello@unina2.it
  • Hongyang Wang          National Center for Liver Cancer, CHN,            hywangk@vip.sina.com

List of Publications (2012 - 2016)
Scientific papers: 68 (plus 4 in revision, submitted, in preparation) with average impact factor 10,94 and on average 100,49 citations per publication, Reviews & Book Chapters: 12, Invited lectures: >130, Patents: 4

  • Amberg N, Holcmann M, Stulnig G, Glitzner E, M. Sibilia. Effects of Depilation Methods on Imiquimod-Induced Skin Inflammation in Mice. J Invest Dermatol. 2017 Feb;137(2):528-531. doi: 10.1016/j.jid.2016.09.018. Epub 2016 Sep 30 No abstract available.
  • Amberg, N., M. Holcmann, G. Stulnig and M. Sibilia, Effects of Imiquimod on hair follicle stem cells and hair cycle progression, J Invest Dermatology, 2016 Nov;136(11):2140-2149. doi: 10.1016/j.jid.2016.06.613.
  • Svinka J, Pflügler S, Mair M, Marschall HU, Hengstler JG, Stiedl P, Poli V, Casanova E, Timelthaler G, Sibilia M, Eferl R. Epidermal growth factor signaling protects from cholestatic liver injury and fibrosis. J Mol Med (Berl). 2016 Aug 27. [Epub ahead of print]
  • Wiedermann U, Sitte HH, Burgmann H, Eser A, Falb P, Holzmann H, Kitchen M, Köller M, Kollaritsch H, Kundi M, Lassmann H, Mutz I, Pickl WF, Riedl E, Sibilia M, Thalhammer F, Tucek B, Zenz W, Zwiauer K. Guidelines for vaccination of immunocompromised individuals. Wien Klin Wochenschr. 2016 Aug;128 Suppl 4:337-76. doi: 10.1007/s00508-016-1033-6. German
  • Schreier, B., M. Hunerberg, S. Rabe, S. Mildenberger, D. Bethmann, C. Heise, M. Sibilia, S. Offermanns, and M. Gekle. 2016. Consequences of postnatal vascular smooth muscle EGFR deletion on acute angiotensin II action. Clin Sci (Lond) 130: 19-33.
  • Schossleitner, K., S. Rauscher, M. Groger, H. P. Friedl, R. Finsterwalder, A. Habertheuer, M. Sibilia, C. Brostjan, D. Fodinger, S. Citi, and P. Petzelbauer. 2016. Evidence That Cingulin Regulates Endothelial Barrier Function In Vitro and In Vivo. Arteriosclerosis, thrombosis, and vascular biology36: 647-654.
  • Satoh, R., K. Kakugawa, T. Yasuda, H. Yoshida, M. Sibilia, Y. Katsura, B. Levi, J. Abramson, Y. Koseki, H. Koseki, W. van Ewijk, G. A. Hollander, and H. Kawamoto. 2016. Requirement of Stat3 Signaling in the Postnatal Development of Thymic Medullary Epithelial Cells. PLoS genetics12: e1005776.
  • Monteforte, R., G. F. Beilhack, R. Grausenburger, B. Mayerhofer, R. Bittner, R. Grillari-Voglauer, M. Sibilia, H. Dellago, E. Tschachler, F. Gruber, and J. Grillari. 2016. SNEV(P) (rp19/) (PSO) (4) deficiency increases PUVA-induced senescence in mouse skin. Experimental dermatology25: 212-217.
  • Komposch, K., and M. Sibilia. 2016. EGFR Signaling in Liver Diseases. International journal of molecular sciences17.
  • Schreier, B., S. Rabe, S. Winter, S. Ruhs, S. Mildenberger, B. Schneider, M. Sibilia, M. Gotthardt, S. Kempe, K. Mader, C. Grossmann, and M. Gekle. 2014. Moderate inappropriately high aldosterone/NaCl constellation in mice: cardiovascular effects and the role of cardiovascular epidermal growth factor receptor. Scientific reports4: 7430.
  • Sayar, B. S., S. Ruegg, E. Schmidt, M. Sibilia, M. Siffert, M. M. Suter, A. Galichet, and E. J. Muller. 2014. EGFR inhibitors erlotinib and lapatinib ameliorate epidermal blistering in pemphigus vulgaris in a non-linear, V-shaped relationship. Experimental dermatology23: 33-38.
  • Ozaki, N., Y. Fukuchi, S. R. Tomiyoshi, H. Uehara, S. Ida, J. Wang, K. Araki, M. Sibilia, H. Baba, K. Yamamura, and M. Ohmuraya. 2014. Autophagy regulation in pancreatic acinar cells is independent of epidermal growth factor receptor signaling. Biochemical and biophysical research communications446: 224-230.
  • Lanaya, H., A. Natarajan, K. Komposch, L. Li, N. Amberg, L. Chen, S. K. Wculek, M. Hammer, R. Zenz, M. Peck-Radosavljevic, W. Sieghart, M. Trauner, H. Wang, and M. Sibilia. 2014. EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation. Nature cell biology16: 972-981, 971-977.
  • Horak, P., E. Tomasich, P. Vanhara, K. Kratochvilova, M. Anees, M. Marhold, C. E. Lemberger, M. Gerschpacher, R. Horvat, M. Sibilia, D. Pils, and M. Krainer. 2014. TUSC3 Loss Alters the ER Stress Response and Accelerates Prostate Cancer Growth in vivo. Scientific reports4: 3739.
  • Glitzner, E., A. Korosec, P. M. Brunner, B. Drobits, N. Amberg, H. B. Schonthaler, T. Kopp, E. F. Wagner, G. Stingl, M. Holcmann, and M. Sibilia. 2014. Specific roles for dendritic cell subsets during initiation and progression of psoriasis. EMBO molecular medicine6: 1312-1327.
  • Alias, S., B. Redwan, A. Panzenboeck, M. P. Winter, U. Schubert, R. Voswinckel, M. K. Frey, J. Jakowitsch, A. Alimohammadi, L. Hobohm, A. Mangold, H. Bergmeister, M. Sibilia, E. F. Wagner, E. Mayer, W. Klepetko, T. J. Hoelzenbein, K. T. Preissner, and I. M. Lang. 2014. Defective Angiogenesis Delays Thrombus Resolution: A Potential Pathogenetic Mechanism Underlying Chronic Thromboembolic Pulmonary Hypertension. Arteriosclerosis, thrombosis, and vascular biology.
  • Zaiss, D. M., J. van Loosdregt, A. Gorlani, C. P. Bekker, A. Grone, M. Sibilia, P. M. van Bergen en Henegouwen, R. C. Roovers, P. J. Coffer, and A. J. Sijts. 2013. Amphiregulin enhances regulatory T cell-suppressive function via the epidermal growth factor receptor. Immunity38: 275-284.
  • Winter, M., M. A. Moser, D. Meunier, C. Fischer, G. Machat, K. Mattes, B. M. Lichtenberger, R. Brunmeir, S. Weissmann, C. Murko, C. Humer, T. Meischel, G. Brosch, P. Matthias, M. Sibilia, and C. Seiser. 2013. Divergent roles of HDAC1 and HDAC2 in the regulation of epidermal development and tumorigenesis. The EMBO journal 32: 3176-3191.
  • Schreier, B., S. Rabe, B. Schneider, M. Bretschneider, S. Rupp, S. Ruhs, J. Neumann, U. Rueckschloss, M. Sibilia, M. Gotthardt, C. Grossmann, and M. Gekle. 2013. Loss of epidermal growth factor receptor in vascular smooth muscle cells and cardiomyocytes causes arterial hypotension and cardiac hypertrophy. Hypertension61: 333-340.
  • Lichtenberger, B. M., P. A. Gerber, M. Holcmann, B. A. Buhren, N. Amberg, V. Smolle, H. Schrumpf, E. Boelke, P. Ansari, C. Mackenzie, A. Wollenberg, A. Kislat, J. W. Fischer, K. Rock, J. Harder, J. M. Schroder, B. Homey, and M. Sibilia. 2013. Epidermal EGFR controls cutaneous host defense and prevents inflammation. Science translational medicine5: 199ra111.
  • Navas, C., I. Hernandez-Porras, A. J. Schuhmacher, M. Sibilia, C. Guerra, and M. Barbacid. 2012. EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma. Cancer cell22: 318-330.
  • Holcmann, M., B. Drobits, and M. Sibilia. 2012. How imiquimod licenses plasmacytoid dendritic cells to kill tumors. Oncoimmunology1: 1661-1663.
  • Eberl, M., S. Klingler, D. Mangelberger, A. Loipetzberger, H. Damhofer, K. Zoidl, H. Schnidar, H. Hache, H. C. Bauer, F. Solca, C. Hauser-Kronberger, A. N. Ermilov, M. E. Verhaegen, C. K. Bichakjian, A. A. Dlugosz, W. Nietfeld, M. Sibilia, H. Lehrach, C. Wierling, and F. Aberger. 2012. Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells. EMBO molecular medicine4: 218-233.
  • Drobits, B., M. Holcmann, N. Amberg, M. Swiecki, R. Grundtner, M. Hammer, M. Colonna, and M. Sibilia. 2012. Imiquimod clears tumors in mice independent of adaptive immunity by converting pDCs into tumor-killing effector cells. The Journal of clinical investigation122: 575-585.
  • Ardito, C. M., B. M. Gruner, K. K. Takeuchi, C. Lubeseder-Martellato, N. Teichmann, P. K. Mazur, K. E. Delgiorno, E. S. Carpenter, C. J. Halbrook, J. C. Hall, D. Pal, T. Briel, A. Herner, M. Trajkovic-Arsic, B. Sipos, G. Y. Liou, P. Storz, N. R. Murray, D. W. Threadgill, M. Sibilia, M. K. Washington, C. L. Wilson, R. M. Schmid, E. W. Raines, H. C. Crawford, and J. T. Siveke. 2012. EGF receptor is required for KRAS-induced pancreatic tumorigenesis. Cancer cell22: 304-317.

 

Reviews, Book Chapters & Special Journal Issues (without peer-review)

  • Holcmann, M., B. Drobits, and M. Sibilia. 2012. How imiquimod licenses plasmacytoid dendritic cells to kill tumors. Oncoimmunology 1: 1661-1663. (IF: 6,283; CI: 13)
  • Savarese F., Holcmann M. and M. Sibilia. 2014, World Cancer Report 2014, Signal transduction and targeted therapy, Bernard Stewart and Christopher P. Wild (Eds.), International Agency for Research on Cancer, WHO, ISBN 978-92-832-0429-9
  • Holcmann M. , N. Amberg, B. Drobits, E. Glitzner, K. Komposch, J. Robson, F. Savarese, S. Srivatsa, G. Stulnig, and M. Sibilia. Mouse Models of Receptor Tyrosine Kinases. Springer 2015. Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease. Wheeler, Deric L., Yarden, Yosef (Eds.)
  • Amberg N., M. Holcmann, E. Glitzner, P. Novoszel, G. Stulnig, and M. Sibilia. 2015. Mouse Models of Non-Melanoma Skin Cancer. In Mouse Models of Cancer. Methods Mol Biol., 1267:217-250.

 

10 Most Important Publications

  • Lanaya, H., A. Natarajan, K. Komposch, L. Li, N. Amberg, L. Chen, S.K. Wculek, M. Hammer, R. Zenz, M. Peck-Radosavljevic, W. Sieghart, M. Trauner, H. Wang and M. Sibilia. 2014. EGFR is required in liver macrophages for IL-1-induced IL-6 production and hepatocellular carcinoma formation. Nature Cell Biology, Aug 31. doi: 10.1038/ncb3031. IF 19.679, CI 16
  • Glitzner E, Korosec A, Brunner PM, Drobits B, Amberg N, Schonthaler HB, Kopp T, Wagner EF, Stingl G, Holcmann M, M. Sibilia. 2014. Specific roles for dendritic cell subsets during initiation and progression of psoriasis. EMBO Mol Med. Sep 12. pii: e201404114. doi: 10.15252/emmm.201404114. [Epub ahead of print] IF 8.25, CI 7
  • Lichtenberger,B.M., P.A. Gerber, M. Holcmann, B.A. Buhren, V. Smolle, H. Schrumpf, E. Boelke, P. Ansari, C. Mackenzie, A. Wollenberg, J. W. Fischer, J. Harder, J. M. Schröder, B. Homey and M. Sibilia. 2013. Epidermal EGFR controls cutaneous host defense and prevents inflammation. Sci Transl Med. Aug 21;5(199):199ra111. doi: 10.1126/scitranslmed.3005886; IF 15.843, CI 37
  • Drobits B., M. Holcmann, N. Amberg, M. Swiecki, R. Grundtner, M. Hammer, M. Colonna, M. Sibilia. 2012. Imiquimod clears tumors in mice independent of adaptive immunity by converting pDCs into tumor-killing effector cells. J. Clin. Invest. Jan 17. [Epub ahead of print] IF 13.215, CI 93
  • Lichtenberger, B. M., P. K. Tan, H. Niederleithner, N. Ferrara, P. Petzelbauer, and M Sibilia.. 2010. Autocrine VEGF signaling synergizes with EGFR in tumor cells to promote epithelial cancer development. Cell 140:268-279. IF 33.116, CI 136
  • Natarajan, A., B. Wagner, and M. Sibilia. 2007. The EGF receptor is required for efficient liver regeneration. PNAS USA 104:17081-17086 IF 9.674, CI 144
  • Wagner, B., A. Natarajan, S. Grunaug, R. Kroismayr, E. F. Wagner, and M. Sibilia. 2006. Neuronal survival depends on EGFR signaling in cortical but not midbrain astrocytes. EMBO J 25:752-762. IF 10,434, CI 57
  • Palamara, F., S. Meindl, M. Holcmann, P. Luhrs, G. Stingl, and M. Sibilia. 2004. Identification and characterization of pDC-like cells in normal mouse skin and melanomas treated with imiquimod. J Immunol 173:3051-3061. IF 4.922, CI 127
  • Sibilia, M.*., A. Fleischmann, A. Behrens, L. Stingl, J. Carroll, F. M. Watt, J. Schlessinger, and E. F. Wagner. 2000. The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development. Cell 102:211-220 (*corresponding author). IF 33.116, CI 235
  • Sibilia, M., and E. F. Wagner. 1995. Strain-dependent epithelial defects in mice lacking the EGF receptor. Science 269:234-238. IF 33.611, CI 715